Short-term versus long-term effects

When you take opioids repeatedly over time, your body slows its production of endorphins. The same dose of opioids stops triggering such a strong flood of good feelings. This is called tolerance. One reason opioid addiction is so common is that people who develop tolerance may feel driven to increase their doses so they can keep feeling good.

Because doctors today are acutely aware of opioid risks, it's often difficult to get your doctor to increase your dose, or even renew your prescription. Some opioid users who believe they need an increased supply turn, at this point, to illegally obtained opioids or heroin. Some illegally obtained drugs, such as fentanyl (Actiq, Duragesic, Fentora), are laced with contaminants, or much more powerful opioids. Because of the potency of fentanyl, this particular combination has been associated with a significant number of deaths in those using heroin.

If you're taking opioids and you've developed tolerance, ask your doctor for help. There are other, safe choices available to help you make a change and continue feeling well. Don't stop opioid medications without a doctor's help. Quitting these drugs abruptly can cause severe side effects, including pain worse than it was before you started taking opioids. Your doctor can help you taper off opioids slowly and safely.